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Modeling, Identification, and Control in Biological and Biomedical Systems



Research lines:

  • Optimal Estimation and Control Problems
  • Analysis and Modelling of Metabolic Systems
  • Methods and Techniques for Neuroengineering
  • Computational Optimization and Optimal Control in Medicine and Biology

Carlo Bruni, Alberto De Santis, Lorenzo Farina, Daniela Iacoviello, Serenella Salinari (leader).

PhD Students:
Federico Papa, Valentina Russo, Ilenia Toppi.

Post Docs:
Laura Astolfi.


The research activity in this area  concerns the development of  general methodologies of modelling, estimation and optimal control theory, as well as  their application in the study of biomedical  and biological systems.   Indeed, researches on biomedical applications were performed since the early 70’s with regard to biomechanics, prostheses and modelling of cellular growth.
At  present, many groups in the Dpt. of Computers and System Sciences, are working in the above mentioned research lines at different levels of engagement. In this context, the main research topics are:

1.    Measurement policy in optimal filtering and control problems;

2.    Statistical modelling of rethinal data for diagnostic purposes;

3.    Modelling and Identification of tumour spheroids response to radiations;

4.    Analysis and modelling of glucose and lipid metabolism and their interaction;

5.     Estimation of cerebral connectivity in humans by means of structural and functional models;

6.    Implementation of devices for Brain Computer Interface based on parameters of the estimated cortical activity or on the real-time analysis of video-sequences;

7.    Medical image analysis, in particular aimed to develop segmentation methods able to enhance the retrieved information  from different kind of images (mammographic data, pupil and liver tissue images etc.);

8.    Computational optimization in applicative topics of systems biology;

9.    Optimal density remodeling for stiffened lightweight structures.

The future activity of the group will  mainly focus on the research on the optimal measurement times in the filtering problems, the study of the mechanisms on the basis of insulin secretion and on the insulin resistance; the investigation about the possible application of the Brain computer Interface techniques in the rehabilitation of stroke subjects; the utilization of the neuroengineering tools in the field of the economy/marketing; the research of optimal policies for tumour radiotherapy, the statistical procedures for automatic diagnosis of retinal pathologies¸ the analysis of the bone  remodeling by finite element analysis  and the optimization of its topology; the computational methods for the analysis of genome wide expression data and the topological features and criticalities in metabolic networks.



Integrazione multimodale di dati EEG, MEG e fMRI per la stima dell’attività e connettività corticale nell’uomo
February 2006 - February 2008 MIUR  -  PRIN

Studio, progetto e realizzazione di algoritmi efficienti di classificazione mediante reti neurali artificiali di immagini di provini metallografici di ghisa sferoidale; modelli dinamici basati su reti neurali artificiali di fenomeni di frattura
January 2006 - January 2008 MIUR  -  PRIN


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