In the last decades several epidemic emergencies have been affecting the world, influ encing the social relationships, the economics and the habits. In particular, starting in the
early 0
80, the Acquired Immunodeficiency Syndrome, AIDS, is representing one of the most
worrying sanitary emergency,...
01a Articolo in rivista
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This paper deals with the problem of cruise itinerary planning which plays a central role in worldwide cruise ship tourism. In particular, the Day-by-day Cruise Itinerary Optimization (DCIO) problem is considered. Assuming that a cruise has been planned in terms of homeports and journey duration,...
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Software transactional memory (STM) provides synchronization support to ensure atomicity and isolation when threads access shared data in concurrent applications. With STM, shared data accesses are encapsulated within transactions automatically handled by the STM layer. Hence, programmers are not...
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Hormonal contraceptives (HCs) have been shown to be safe and effective when used correctly and consistently, however, as other classes of drugs, they are also associated with adverse health outcomes. In this study, we aim to explain the occurrence of common and unexpected HCs side effects (SEs)...
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Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approachBackground: Immune checkpoint inhibitors (ICIs) have particular, immune-related adverse events (irAEs), as a consequence of interfering with self-tolerance mechanisms. The incidence of irAEs varies depending on ICI class, administered dose and treatment schedule. The aim of this study was to define...
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Drug repurposing strategy, proposing a therapeutic switching of already approved drugs with known medical indications to new therapeutic purposes, has been considered as an efficient approach to unveil novel drug candidates with new pharmacological activities, significantly reducing the cost and...
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Despite advances in modern medicine that led to improvements in cardiovascular outcomes, cardiovascular disease (CVD) remains the leading cause of mortality and morbidity globally. Thus, there is an urgent need for new approaches to improve CVD drug treatments. As the development time and cost of...
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Background: Gene expression is the result of the balance between transcription and degradation. Recent experimental findings have shown fine and specific regulation of RNA degradation and the presence of various molecular machinery purposely devoted to this task, such as RNA binding proteins, non-...
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Factor graphs are graphical models used to represent a wide variety of problems across robotics, such as Structure from Motion (SfM), Simultaneous Localization and Mapping (SLAM) and calibration. Typically, at their core, they have an optimization problem whose terms only depend on a small subset...
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Ego-motion estimation is a fundamental building block of any autonomous system that needs to navigate in an environment. In large-scale outdoor scenes, 3D LiDARs are often used for this task, as they provide a large number of range measurements at high precision. In this paper, we propose a novel...