A cruise company faces three decision problems: at a strategic level, to decide in which maritime area and in which season window to locate each ship of its fleet; at a tactical level, given a ship in a maritime area and in a season window, to decide which cruises to offer to the customers; at an...
01a Articolo in rivista
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Software transactional memory (STM) provides synchronization support to ensure atomicity and isolation when threads access shared data in concurrent applications. With STM, shared data accesses are encapsulated within transactions automatically handled by the STM layer. Hence, programmers are not...
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Nowadays, the role played by registries in monitoring and improving healthcare, including the quality of medical devices, is widely recognized. A well-designed digital healthcare registry, in particular regarding data collection procedures and tools, can effectively support goals such as monitoring...
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The large diffusion of multi-core machines has pushed the research in the field of Parallel Discrete Event Simulation (PDES) toward new programming paradigms, based on the exploitation of shared memory. On the opposite side, the advent of Cloud computing—and the possibility to group together many (...
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In the context of aerospace engineering, the optimization of processes may often require to solve multi-objective optimization problems, including mixed variables, multi-modal and non-differentiable quantities, possibly involving highly-expensive objective function evaluations. In Air Traffic...
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Failures in computer systems can be often tracked down to software anomalies of various kinds. In many scenarios, it could be difficult, unfeasible, or unprofitable to carry out extensive debugging activity to spot the causes of anomalies and remove them. In other cases, taking corrective actions...
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Hormonal contraceptives (HCs) have been shown to be safe and effective when used correctly and consistently, however, as other classes of drugs, they are also associated with adverse health outcomes. In this study, we aim to explain the occurrence of common and unexpected HCs side effects (SEs)...
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Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approachBackground: Immune checkpoint inhibitors (ICIs) have particular, immune-related adverse events (irAEs), as a consequence of interfering with self-tolerance mechanisms. The incidence of irAEs varies depending on ICI class, administered dose and treatment schedule. The aim of this study was to define...
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Drug repurposing strategy, proposing a therapeutic switching of already approved drugs with known medical indications to new therapeutic purposes, has been considered as an efficient approach to unveil novel drug candidates with new pharmacological activities, significantly reducing the cost and...
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Despite advances in modern medicine that led to improvements in cardiovascular outcomes, cardiovascular disease (CVD) remains the leading cause of mortality and morbidity globally. Thus, there is an urgent need for new approaches to improve CVD drug treatments. As the development time and cost of...