 Katherine Heigl (qv) tested for all three female leads before  landing the part of Isabel Evans. Before winning the role of Maria  DeLuca, Majandra Delfino (qv) originally auditioned for the part  of Liz, which eventually went to Shiri Appleby (qv) who, like  Heigl, tested for all three female lead roles, winning the lead of  Liz Parker after several callbacks.