 Due to the weight he gained for the film, George Clooney (qv)  suffered a spinal injury during a stunt that caused him severe  migraine headaches (which prevented him from doing publicity for  _Oceans Twelve (2004)_ (qv)), and had him bedridden for a month.  This injury was eventually corrected with surgery, and Clooney has  since called his weight gain "pretty stupid".