 In the second series episode to deal with bubonic plague, the U.S. Coast Guard finds a schooner adrift off the coast of Oahu, and calls Five-O when it also finds three crew members murdered. McGarrett is called in, and finds the boat is rat-infested -- the crew members had all caught bubonic plague. McGarrett is also exposed to the disease, and is taken to an isolation ward. Further investigation reveals that three people -- a Corsican gangster named Paoli, his daughter Theresa and Theresa s husband Thomas Brown -- had charted the schooner to take them across the Pacific from Asia, where Paoli had recently withdrawn $5 million in mob funds. The trio goes underground in Honolulu s seedy netherworld and can t be located, so the Governor declares the whole island in a state of quarantine -- no flights can depart Honolulu International Airport and no boats can leave without all passengers being checked out. As Theresa goes downhill steadily, Thomas Brown gets a shot of a plague vaccine (Danno, to a mobster who met Brown): "Tetracycline isn t worth a damn for someone who already has the plague ... by the way, have you had your shot?") and searches for a clandestine way to get off the island. Theresa dies of the disease and Brown shoots Paoli, who goes down literally spitting curses at him. Brown then manages to get a helicopter to come from Hilo to an isolated part of Oahu, where he can fly to the Big Island and get to the mainland via the Hilo airport. After interrogating the mobster and revealing Brown s true nature to him ("That lying son of a ...!") Danno gets directions to the takeoff point and it becomes a race against time.