 When Danny Tanner s wife Pamela is killed in an auto accident, he finds himself left all alone to raise his three daughters: D.J., Stephanie, and baby Michelle. Fortunately Danny s hair-obsessed, rock-star brother in-law Jesse Cochran, along with Danny s flamboyant, cartoon loving friend Joey Gladstone, move in to help Danny raise his girls. On the first day, D.J. runs away, and Jesse and Joey find extreme difficulty and anxiety in changing Michelle.