 The Girardis have moved to the small town of Arcadia from the big city after patriarch Will gets a job as chief of police. Middle child Joan isn t happy, and her family, consisting of science nerd Luke, paralyzed former jock Kevin, and their perpetually flustered mother Helen, isn t helping. Then, Joan finds herself speaking to God, in the form of various people who give her assignments to help those around her. As her friendship with the zoned out avant garde sculptor Adam Rove and androgynous rebel Grace develops, Joan keeps following God s assignments, never sure if she s really just going crazy.