 After producer Minnie Mogul (Janeane Garofalo) signs a contract that brings cartoon villains Fearless Leader (Robert De Niro), Boris Badenov (Jason Alexander), and Natasha Fatale (Rene Russo) start a villainous TV station "RBTV (Really Bad TeleVision)", warm-hearted FBI Agent Karen Sympathy (Piper Perabo) must obtain the help of Rocky and Bullwinkle to help to save the country from being hypnotized by Fearless Leader s plan.