 In the future, in a polluted post-apocalyptic society called Eurasia after a war against Europe, the planet is devastated by the effect of nuclear, biological and chemical weapons. The geneticist Dr. Azuma (Akira Terao) develops a technique called "neo-cell", capable of regenerating the body of human beings, sponsored by an evil corporation. His son Tetsuya Azuma (Yusuke Iseya) dies in the war, but after an accident in the laboratory of Dr. Azuma, Tetsuya revives as the powerful warrior Casshern, while a new breed of mutants called "neo-humans" is generated in the plant. The neo-humans decide to annihilate the humans and raise a new world.