 Bernie Mac is a world famous stand-up comedian living the good life in his Los Angeles home complete with beautiful wife, Wanda, and a hi-tech SUV. Life was sweet for the Mac-Man. Then one day, Bernie s sister, in Chicago, is sent to rehab for drug use and her three children: teenage Vanessa, asthmatic wheezing Jordan and sweet, innocent Bryana, are put into Bernie s custody. Raising kids is hard! Especially these kids. They always give poor Uncle Bernie trouble, making him want to "bust their heads  til the white meat shows".