 Sheila Sabatini (Nichola McAuliffe) is a brilliant surgeon, but her sharp tongue gets her into trouble with fellow consultant surgeons George Hope-Wynne (David Conville) and Neil Copeland (Emlyn Price). They think she s a "ghastly woman", mainly because she likes to unearth their lazy and hypocritical behaviour at every opportunity. However, her best friend Joyce (Marji Campi) and her anaesthetist Jonathan Haslam (Duncan Preston) thinks she s marvellous. Can she make it in the hospital s old boy network, keep her relationship with her teenage son at least semi-functional at the same time as sorting out how she feels about Jonathan?