 In Chicago, the waitress Meredith Mcdonell is pursued by a shadow in a alley, and once locked at home, she is slashed and her heart is stolen. Dean and Sam move to Chicago to investigate two similar murder cases, and while in the bar where Meredith worked, Sam meets Meg. Sam does not believe in serendipity, and follows Meg to an old warehouse where she worships a demoniac god. Meanwhile, Dean leaves a message to his father asking for help to fight against the shadow fiend. When John Winchester meets his sons, they realize that they have been ambushed by evil forces.