 Ted introduces the series on wine by meeting a selection of people who have devoted their lives to it: grape growers, wine makers, wine writers, and chefs who cook with wine. After visiting some vineyards, Ted talks to Food&Wine magazine editor Lettie Teague, who explains how she educated Rolling Stone magazine critic Peter Travers, who she calls "the most wine ignorant man she knew." Ted then moves on to the technical side, defining wine terminology, and teaching how the senses smell, feel, sight and most importantly taste are used to appreciate wine, ending with him comparing taste notes on the ten top grape varieties used in wine making. The episode finishes with a brief look at some of the most famous wine producing regions worldwide.