 Drake and Josh are brothers that are left alone while their parents go to a ten-day cruise. They have to get their sister (Megan) to Denver. While they are at the airport they order a ticket to Denver but put her in a plane to L.A. They follow her to L.A and try to find her. Megan asks a limo to drop her off at the greatest hotel in the world. Drake and Josh ask people if they saw a little girl. A man says," at the finest hotel." At the hotel Josh goes to the bathroom and sees the director of TRL. The director is troubled because he doesn t have another band to play in TRL. Josh pushes a laptop under the stall while the director was talking on the phone and the director sees Drakes band play and gives them a music gig. But the people that told Drake and Josh where Meagan was are up to something illegal and it s up to Drake and Josh to stop them. Will Drake and Josh find Megan, go to TRL and stop the bad guys in time???!