 In a lonely road in Cape Girardeau, Missouri, a black man driving a car is chased and hit by a truck, falling off-road and dying. His daughter Cassie Robinson calls her former boyfriend Dean and asks him to investigate the mysterious accident. Sam and Dean see that three Afro-Americans and the Caucasian Major of the town were killed in weird accidents on the same road. When the truck threatens Cassie, her Caucasian mother Mrs. Robinson tells a tragic racist murder that happened thirty years ago, and the brothers realize that they have to fight against a hatred spirit in a ghost truck.