 Winekta, Illinois. One year after the death of their father from a long battle with cancer, the four very different sisters of the Reed family try to put aside their personal differences and help their widowed, alcoholic mother, Beatrice, sell her house. Alex, the eldest of the sisters, is a wealthy and snobbish, WASP wife of Wade Halsey, a plastic surgeon, with a teenage daughter, Reed, and is too self-involved with her perfect life to notice anything else, until she s forced to bail out her own mother from jail when she s arrested for drunk driving. Georgie is a real estate agent who takes over as the matriarch of the family to support it and her two sons, Trevor and Evan, when her flaky, unemployed husband, John Whitsig, confides himself to their house and singing karaoke in his bathrobe after suffering a nervous breakdown since losing his job. Teddy, the second oldest of the sisters, is a free-spirited drifter and artist who arrives in town after years of living on the road with her teenage daughter Cat and tries to win back her ex-husband Mitch Margolis, a fish store owner, whom is now romantically involved with the youngest sister Frankie, an ambitious marketing analyst living in nearby Chicago.