 All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman s prognosis is not good. Now that Bailey knows about Meredith and Derek s affair, their jobs are in jeopardy, and she strongly advises Meredith to end it. Meanwhile, Cristina and Burke s secret relationship gets more complicated, and when no one else can be reached, Izzie has to perform a major procedure on her own.