 Carl Houser (Theodore Newton) secretly loads up a money belt in the bank where he works, and takes his wife Anna (Lurene Tuttle) on a cruise. Coincidentally, Perry Mason and Della Street are on the same ship, along with a patient whose face is completely covered with bandages. One night, Carl disappears overboard, and Anna is charged with murder. The investigation clears Carl of embezzlement, but the Chicago mob might somehow be involved. The questions for Perry are: who has jurisdiction in the case, and where is the mysterious patient?