 When Ms. Glass asks the glass to write down where they went on spring break and how many people they slept with, the Kennedy High students are quarantined at the school after Harrison shows symptoms of an exotic disease, Rip Valley Fever, he may have contracted during his vacation in Yemen. He and Sam are locked up in the nurses station together forcing them to face their feelings for each other. In a hilarious "I Know What You Did Last Summer" spoof, the kids are hunted by a mysterious killer who knows what each of them did. Mary Cherry is the first to get the call from the killer having spent her spring break trying out for a bad horror movie willing to do anything to be a scream queen, anything. The gang all split up after finding out the odds of their plane crashing are 1:1. Harrison tells Sam that he met a girl while in Yemen, and when asked by Sam if he slept with her he tells her no, cause it wasn t her. Josh is the next target of the killer while showering in the boys locker room where the killer leaves a photo of him and Lily that could result in him being suspended from school, resulting in a towel chase. They decide to figure out who could possibly be the killer by interrogating Ms Glass, April Tuna and Nicole, all but Josh and Lily thinking Nicole could be the killer. Josh and Lily went back to the school to have a romantic diner where they first met when Nicole finds them, threatening to turn them for drinking alcohol on school premises. She offers not to turn them in if he kisses her, opting to pull hair from the boys locker room drains then kiss her, which she makes them do. Sam tells Harrison about how she spent her vacation at George s house, where she meets his mother and grandmother finding out that he has yet to tell his grandmother about them dating. Feeling he is ashamed of her cause his grandmother pouted for weeks when his brother dated a white girl thinking he no longer loves her and left. In a weak moment Harrison and Sam share a kiss when George walks in on them after breaking into the school to get Sam some help. He reveals he told his grandmother about her and she likes Sam, turns out that his grandmother didn t like his brothers girlfriend because of her character. In an attempt to lure the killer Nicole and Brooke dress up in sexy lingerie, Brooke feels ridiculous leaving Nicole to be the damsel in distress. Sam feels her kiss with Harrison was a mistake and when he asks her to tell him that she felt nothing when they kissed she can t. Harrison breaks the window open letting Sam out to run back to George and stop tormenting him. Nicole is unable to lure the killer out, which Carmen points out that usually killers in horror films are attracted to virgins. Lily and Josh become the decoy luring April Tuna and not the killer. Ms Glass becomes the next target of the killer who proves to easy a target when she is not frightened and wants the killer to kill her. Brooke and George have a talk where Brooke lets it slip that she knows that Harrison isn t sick and she knows what he did for spring break. The real CDC woman shows up breaking into the school finding out that the phony CDC woman is the travel agent that they screwed over when they canceled their vacation. She had earned her own spring break of a life time loosing her compensation bonus vowing revenge. After the real CDC doctor examines Harrison she gives him a clean bill of health as the sun comes up. George and Brooke force Harrison to tell Sam what he really did for spring break. After Brooke finds Jamie with his ex-girlfriend she ran into Harrison at a hotel and hung out together. They talked about love and hurting ones they love, sharing a moment that brings them closer together in an intimate way. Breaking everyone s heart especially Sam s who walks away from Harrison this time never wanting to see him again.