 While in the P3 slicing Kino not inspected by the Health Department, Piper collapses and is moved to the San Francisco Memorial Hospital. The specialist Dr. Curtis Williamson finds that she has Oroya Fever, a very rare disease. Meanwhile, Prue is working in the authentication of a Monet. When Piper gets into a coma, Dr. Williamson tells Pru and Phoebe that Piper has to pull out of the coma by herself. Leo is contacted by Prue and Phoebe, but he informs that he is not allowed to heal Piper. The sisters decide to cast an awakening spell to save Piper, but their personal gain causes an outbreak in the hospital and the Center of Disease Control (CDC) is called, with dramatic consequences for the sisters and Leo.