 Doctors in an underwater laboratory discover a chemical in the brains of sharks capable of reviving human brain cells. Using gene therapy the doctors create sharks with larger brain masses as a way to speed up the production of the life saving antidote. The result is a breed of Mako that is bigger, stronger, smarter, faster and more fierce then anything man has seen before. The sharks gain the ability to reason and turn on their masters resulting in an all or nothing fight to the finish between man and the ultimate predator.