 A group of research scientists, working in an abandoned off-shore submarine facility, appear to have discovered a neuro-stimulant, extracted from the brains of sharks, that cures Alzheimer s disease. However, unknown to the rest of the researchers the project leaders Dr. Susan McAlester ( Saffron Burrows  (qv)) and Jim Whitlock ( Stellan Skarsgård  (qv)) have illegally used proscribed gene manipulation techniques to enhance the brain size of the sharks to attain their spectacular results. During a severe storm, whilst the researchers are celebrating their success, the newly intelligent sharks attack their captors in a bid to escape. As a result of the storm and the sharks attack strategy, the research facility suffers a catastrophic structural integrity failure and begins to submerge. The situation becomes a deadly race against time as the survivors, led by shark wrangler Carter Blake ( Thomas Jane  (qv)) and Preacher ( LL Cool J  (qv)), try to reach the surface and safety as the deadly intelligent killer-sharks continue to flood the facility and hunt their prey. Everything is at stake for the winners of this deadly game of hunter and hunted!