 Twenty-two years ago, in Lawrence, Kansas, a family is attacked by a poltergeist and Mary, the mother of the brothers Sam and Dean, is burned to death in front of their father John Winchester, who dedicates his life from this moment on chasing the evil spirit that killed his beloved wife. In the present days, Sam moved to Stanford University, where he is living with his girlfriend Jessica. One Friday night, his brother Dean shows up in Sam s place and tells him that their father is missing, and asks Sam to help him to track the last steps of John. They drive to Jericho, California, and arrive in a small town called Centennial, where the urban legend tells the story of a hitchhiker highway killer, actually a violent fiend called "The Woman in White." Together, the brothers face the diabolic Constance Welsh and their desire of revenge.