 After a construction worker is killed by insects burrowing into his brain, Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate the town s history and find that the new housing development is being built on sacred Indian land. The Indians put a curse on the land after their reservation had been ravished and destroyed. Sam and Dean must find a way to survive and kill the deadly swarm of bees, locusts, spiders and beetles.