 The Dukes find themselves tangling with a new, meaner adversary in Chickasaw County Sheriff "Big" Ed Little. This, after Bo develops amnesia after an accident and Boss convinces the young Duke that he is actually Bo Hogg, the Hoggs  long-lost son. Boss convinces Bo to drive a shipment to Chickasaw, not telling him that the delivery is moonshine. He then tips Sheriff Little about a rumored moonshine runner, forcing Luke and Daisy to race against time to save their cousin from prison.