 At least a millenium into the future, the Terran Alliance is at war with the Morthan Solidarity, a race of genetically-augmented humans bred specifically for warfare. The show follows the adventures of one destroyer-type liberty ship, the LS-1187 or "Star Wolf," the ship that inadvertently led the Morthans to a heavily-guarded shipping convoy and massacred a good portion of the Alliance fleet and is consequently considered a pariah.