 Denny s father ( Fred Ward (I)  (qv)) visits Izzie and gives her something that will change everything. Meanwhile, Meredith is diagnosed with appendicitis and while waiting for emergency surgery and high on morphine has a talk with Addison for the first time since Addison found the panties. Mark "McSteamy" Sloan starts working at the hospital and Alex wants to work under him instead of Addison because Mark has a patient with severe facial burns. And while Callie and George break up, Meredith finally picks one man.