 In Rockford, Illinois, while investigating possible trespassers in the South Wing of the Roosevelt Hospital, two policemen find a group of teenagers drinking in the place. One of the policeman drives insane and kills his wife, committing suicide immediately after. Dean receives a message in his cellular with the coordinates of the asylum, and drives with Sam to the place. The brothers disclose that the patients riot against the director, Dr. Ellicott, who conducted painful and cruel experiments with the patients and his body has never been found. Further, that there is a local legend that any person that spend the night in the asylum, the spirits drive he or she crazy. Together with Kat and Gavin, a young couple that is trapped in the Asylum, Dean and Sam spend the night in the cellar of the South Wing trying to find the hidden body of Dr. Ellicott to burn it and destroy the fiend.