 Joey (Matt LeBlanc) moves from Manhatten to Hollywood to pursue his acting career. He soon meets up with his sister Gina, (Drea DeMatteo) and his nephew Michael (Paulo Costanzo). Joey takes a shine to his new neighbor Alex (Andrea Anders) but later discovers she is married. After he turns down a hit show called "Nurses" and his other show is canceled for being "disgusting" Joey turns to his agent Bobbie (Jennifer Coolidge) to find him something else... Michael moves in with his Uncle Joey after Joey gives a speech about how change can be good to Gina. She understands that she must let her son move on.