 Alexander Kline, a brilliant scientist who had worked for the U.S. government, creates the Q strain, a bacteria that can wipe out vast numbers of people in a short time. He quit his U.S. position. To protest research into biological weapons, he will use the Q strain to wipe out Hawaii s population. Five-O catches up to Kline but the scientist has already left a vial with the killer bacteria in a place where it will spread.